Vidya Chandrasekaran

Vidya Chandrasekaran

Overview

Department: 
School of Science » Biochemistry
School of Science » Biology
SMC Email Address: 
Contact Information: 

Office
Brousseau Hall - 208

Contact:
Phone: 631 4251
Email: vc5@stmarys-ca.edu

Education

  • Postdoctoral Research Molecular and Cell Biology, University of California at Berkeley, May 2005
    Genetics of organ formation in fruit flies (Drosophila melanogaster)
  • Ph.D Pharmacology and Toxicology, State University of New York at Buffalo, August 1999
    Regulation of dendritic growth in rat sympathetic neurons

Courses Taught

Recently Taught:

  • Bio 001 : Introduction to Cell Biology, Molecular Biology and Genetics
  • Bio 25: Human Physiology
  • Bio 102: Developmental Biology
  • Bio 105 : Genetics
  • Bio 127: Systemic Physiology
  • Bio 130: Microbiology
  • Bio 132: Cell Biology
  • Bio 135: Biochemistry

Service

SMC:

  • 2009 - 2012: Core Curriculum Implementation Committee
  • 2007 - present: Faculty Development Fund
  • 2013 - 2016 : Chair, Department of Biology
  • 2014 - present: Chair, Institutional Animal Care and Use Committee
  • 2015 - present: Member, Rank and Tenure Committee
  • 2017 - present : Chair, Rank and Tenure Committee
     

Professional:

  • Reviewer - Developmental Biology
    (2007)
  • Reviewer - Neurotoxicology
  • Member of Genomics Education Partnership
  • ASCB member
  • ASPET member

 

    Presentations

    Chandrasekaran V., Lea C. and Lein P.J.: Free radicals are important for dendritic growth in rat embryonic sympathetic neurons. FASEB J March 29, 2012 26:845.6

     

    Lea C., Lein P.J. and Chandrasekaran V.: Reactive Oxygen Species are important for promoting BMP-induced dendritic growth in rat embryonic sympathetic neurons. West Coast Biological Science Undergraduate Research Conference, 2011. (Poster)

     

    Shide E., Doyle W and Chandrasekaran V.: The effects of energy drinks on the structure and function of epithelial cells and fibroblasts. West Coast Biological Science Undergraduate Research Conference, 2011. (Poster)

     

    Doyle W and Chandrasekaran V.: Embryonic and cellular effects after exposure to commonly consumed energy drinks FASEB J, 2011 25:749.3 (Poster)

     

    Schibler J and Chandrasekaran V.: The role of CG11148 in embryogenesis and wing patterning in Drosophila: A.Dors.Res.Conf. 51, 2010 (Poster).

     

    Elgin S.C.R, Chandrasekaran V, Chung H.M, Coyle-Thompson C, Johnson D, Jones C.J, Kokan N, McNeil G, Nagengast A, Saville K, Stamm J, Wawersik M and Lopatto D. : Genomics Education Partnership.: A. Dros. Res. Conf. 50, 2009. (Poster)

     

    Solarewicz V, Beckendorf S.K and Chandrasekaran V.: The role of taiman in the formation of Drosophila embryonic salivary glands.: A. Dros. Res. Conf. 50, 2009 (Poster)

     

    Chandrasekaran V and Beckendorf S.K.: The role of Btk29A in the morphogenesis of embryonic salivary glands.: A. Dros. Res. Conf. 45, 2004. (Poster)

     

    Chandrasekaran V and Beckendorf S.K.: The role of Btk29A in the morphogenesis of embryonic salivary glands.: A. Dros. Res. Conf. 44, 2003. (Poster)

     

    Chandrasekaran V and Beckendorf S.K.: senseless controls the survival of cells in the salivary glands by repressing reaper and hid: A. Dros. Res. Conf. 43, 2002. (Platform)

     

    Chandrasekaran, V., Zhou, B. and Beckendorf, S.K.: senseless is necessary for the survival of embryonic salivary gland precursors: A. Dros. Res. Conf. 42, 2001. (Poster)

     

    Dattatreyamurty B., Roux E., Kaplan P.L., Lein P.J., Higgins D. and Chandrasekaran V.: Cerebrospinal fluid contains biologically active bone morphogenetic protein –7: Society for Neuroscience, 1999. (Poster)

     

    Chandrasekaran V., Hedges A.M., Rueger D. and Lein P.J.: Glial induction of dendritic growth in rat sympathetic neurons involves osteogenic protein –1 (OP-1): American Society of Cell Biology, 1995. (Poster)

     

    Chandrasekaran V and Higgins D.: Retinoic acid regulates dendritic growth in rat sympathetic neurons. Eastern Students Research Conference, 1998. (Platform)

    Publications

    Chandrasekaran V, Lea C, Sosa C, Higgins D and Lein PJ, Reactive Oxygen Species are Involved in BMP-Induced Dendritic Growth in Cultured Rat Sympathetic Neurons. Mol Cell Neurosci. 67:116-25, 2015.

    Leung, W, ….. Chandrasekaran V, ..., Elgin, SCR, The Drosophila Muller F elements maintain a distinct set of genomic properties over 40 million years of evolution. G3. 5(5):719-40, 2015.

    Lopatto D, Hauser C, Jones CJ, Paetkau D, Chandrasekaran V, Dunbar D, MacKinnon C et. al., A Central Support System Can Facilitate Implementation and Sustainability of a Classroom-Based Undergraduate Research Experience (CURE) in Genomics. CBE Life Sci Educ. 13(4):711-23, 2014.

    Shaffer CD, Alvarez CJ, Bednarski AE, Dunbar D, Goodman AL, Reinke C, Rosenwald AG, Wolyniak MJ, Bailey C, Barnard D, Bazinet C, Beach DL, Bedard JE, Bhalla S, Braverman J, Burg M, Chandrasekaran V, Chung HM, Clase K et.al., A course-based research experience: how benefits change with increased investment in instructional time. CBE Life Sci Educ.13(1):111-30. 2014.

    Doyle W, Shide E, Thapa S and Chandrasekaran V.: The effects of energy beverages on cultured cells. Food and Chemical Toxicology, 50: 3759-3768, 2012.

    Wolyniak M.J, Alvarez C J, Chandrasekaran V, Grana T A, Holgado A, Jones C.J, Morris R.W, Pereira A L, Stamm J, Washington T.M, and Yang Y.: Building better scientists through cross-disciplinary collaboration in synthetic biology: a meeting report from the genome consortium for active teaching (GCAT) workshop 2010. CBE—Life Sciences Education, 9(4): 399–404, 2010

    Shaffer C.D, Alvarez C, Bailey C, Barnard D, Bhalla S, Chandrasekaran C, Chandrasekaran V, Chung H, Dorer D.R, Du C, Eckdahl T.D, Poet J, Frohlich D, Goodman A.L, Gosser Y, Hauser C, Hoopes L.M., Johnson D, Jones C.J, Kaehler K, Kokan N, Kopp O.R, Kuleck G, McNeil G, Moss R, Myka J, Nagengast A, Morris R, Overvoorde P.J, Shoop E, Parrish S, Reed K, Regisford G, Revie D, Rosenwald A.E, Saville K, Schroeder S, Shaw M, Skuse G, Smith C, Smith C, Spana E.P, Spratt M, Stamm J, Thompson J.S, Wawersik M, Wilson B.A, Youngblom J, Leung W, Buhler J, Mardis E.R, Lopatto D, and Elgin S.C.R.: The Genomics Education Partnership: Successful Integration of Research into Laboratory Classes at a Diverse Group of Undergraduate Institutions. CBE—Life Sciences Education, 9(1) 55-69, 2010.

    Chandrasekaran V. and Beckendorf S. K.: Tec29 controls actin remodeling and endoreplication during the invagination of the Drosophila embryonic salivary glands. Development, 132: 3515-24, 2005.

    Chandrasekaran V. and Beckendorf S. K.: senseless is necessary for the survival of embryonic salivary gland precursors in Drosophila. Development, 130: 4719-28, 2003.

    Lein P.J., Beck H., Chandrasekaran V., Gallaghar P.J., Chen H, Lin Y, Guo X., Kaplan P.L., Tiedge H. and Higgins D.: Glia induce dendritic growth in cultures sympathetic neurons by modulating the balance between bone morphogenetic proteins (BMPs) and BMP antagonists. J. Neurosci., 22: 10377-10387, 2002.

    Horbinski C., Stachowiak, E.K., Chandrasekaran V., Miuzukoshi E., Higgins D. and Stachowiak M.K.: Bone morphogenetic protein-7 stimulates initial dendritic growth in sympathetic neurons through an intracellular fibroblast growth factor signaling pathway. J. Neurochem., 80: 54-63, 2002.

    Dattatreyamurty B., Roux E., Kaplan P.L., Roback L.A., Horbinski C., Lein P., Higgins D. and Chandrasekaran V.: Cerebrospinal fluid contains biologically active bone morphogenetic protein –7. Exp. Neurol., 172: 273 – 281, 2001.

    Chandrasekaran V., Zhai Y., Wagner M., Napoli J.L., Kaplan P.L. and Higgins D.: Retinoic acid regulates the morphological development of sympathetic neurons. J. Neurobio., 42: 383 – 393, 2000.

    Guo X., Chandrasekaran V., Lein P.J., Kaplan P.L. and Higgins D.: Leukemia inhibitory factor and ciliary neurotrophic factor cause dendritic retraction in cultured sympathetic neurons. J. Neurosci., 19: 2113 - 2121, 1999.

    Active Research Projects

    Dendritic growth regulation during embryonic development and injury

    Neurons have two main processes : axons for transmitting information and dendrites for receiving signals. Axons and dendrites differ in length, morphology and in the signals that control their growth. During neuronal injury, it is known that loss of axons results in dendritic retraction. Therefore, it is important to understand the signals that are involved in extension and retraction of dendrites. One of the molecules that is known to induce dendritic growth belongs to a class of growth factors known as Bone Morphogenetic Proteins or BMPs.

    My lab currently focuses on three main research projects :

    • understanding post-transcritional control of dendritic growth in embryonic sympathetic neurons mediated by microRNAs

    • Interactions between BMP signaling and other signaling pathways during dendritic growth regulation

    • Examining the changes to the proteome during dendritic growth regulation in these neurons.

     

    Cell and Developmental Biology, Genetics

    Organ formation is a fascinating process during embryonic development. Among the many organs in the body, there is a preponderance of tubular organs, including stomach, intestine, heart and blood vessels, several glands, lungs in humans, trachea in lower vertebrates. I am also interested in understanding the cell biological processes underlying formation these organs as well as the genes that help differentiate cells forming one organ from cells forming another organ. I have been examining the evolutionary conservation of genes required for salivary gland formation in Drosophila.

     

     

    Honors, Awards & Grants

    Grants: 

    2017 - 2018 : Faculty Research Award, Saint Mary's College ($9000)

    2016 - Present: Co-PI, US Dept. of Education HSI-STEM grant, $2,700,000

    2014 - 2017 : Co-PI, NSF-S-STEM grant ($613,477).

    2017 -  PI, NIH AREA grant ($330,000) - Pending